MYELOID NEOPLASIA Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome
نویسندگان
چکیده
1Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, Australia; 2Division of Blood Cancers, Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia; 3Genomics and Systems Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia; 4Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; 5The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; 6Department of Medical Biology, The University of Melbourne, Melbourne, Australia; and 7Department of Clinical Hematology, Alfred Hospital, Melbourne, Australia
منابع مشابه
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome.
Programmed cell death or apoptosis is a prominent feature of low-risk myelodysplastic syndromes (MDS), although the underlying mechanism remains controversial. High-risk MDS have less apoptosis associated with increased expression of the prosurvival BCL2-related proteins. To address the mechanism and pathogenic role of apoptosis and BCL2 expression in MDS, we used a mouse model resembling human...
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